Major Events
- Mar 27 Spaniard Juan Ponce de León and his expedition first sight Florida
- Apr 2 Explorer Juan Ponce de León claims Florida for Spain as the first known European to reach Florida
- Sep 25 Spanish explorer Vasco Nunez de Balboa crosses the Panama Isthmus becoming first European to see the Pacific Ocean
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Born in 1513
- Feb 14 Domenico Maria Ferrabosco, Italian Renaissance composer and singer, born in Bologna, Papal States (d. 1574)
- Jul 9 John van Hembyze, Flemish Calvinist, born in Ghent, Belgium (d. 1584)
- Jul 20 Gaspar Schetz, Dutch nobleman and financier (royal treasurer general of the Habsburg Netherlands), born in Antwerp, Duchy of Brabant, Holy Roman Empire (now Belgium) (d. 1580)
- Sep 24 Catherine of Saxe-Lauenburg, Queen of Gustav I of Sweden, born in Ratzeburg, Germany (d. 1535)
- Oct 30 Jacques Amyot, French humanist, translator and Abbot of Bellozanne, born in Melun (d. 1593)
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