- Apr 2 Jacques Bondon, French composer, dies at 80
- Apr 12 Danny Davis [George Nowlan], American session trumpeter, pop-country music bandleader (The Nashville Brass - "I Saw the Light"), singer (Speed Racer theme), and record producer (Connie Francis), dies of a heart attack at 83
- Apr 14 Esbjörn Svensson, Swedish jazz pianist (Seven Days Of Falling), dies in scuba diving accident at 44
- Apr 15 Brian "Blinky" Davison, British rocker (The Nice), dies at 65
- Apr 15 Sean Costello, American blues guitarist and singer, dies of multiple drug intoxication at 28
- Apr 17 Danny Federici, American rock organist, accordionist, and glockenspieler (E Street Band), dies of melanoma at 58
- Apr 19 Richard de Bois, Dutch songwriter ("Ik Hou Van Jou"), record producer (Dollly Dots); Ivy Green), and drummer (Roek's Family; Ginger Ale), dies of cancer at 59
- Apr 20 Frank Michael Beyer, German composer, organist, and educator, dies at 80
- Apr 20 VL Mike [Michael Allen], American rapper, shot to death by unknown assailant at 32
- Apr 21 Al Wilson, American soul singer ("Show and Tell"; "The Snake"), dies of kidney failure at 68
- Apr 22 Paul Davis, American country-rock-pop singer-songwriter and piano player ("I Go Crazy"; "65 Love Affair"), dies of a heart attack at 60
- Apr 25 Humphrey Lyttelton, British jazz trumpeter and bandleader ("Bad Penny Blues"), and broadcaster (BBC2 - Best Of Jazz, 1967-2007; BBC4 - I'm Sorry I Haven't A Clue, 1972-2008), dies at 86
- Apr 26 Henry Brant, American composer (Great American Goot), dies at 94
- Apr 29 Michael "Micky" Waller, British blues and rock drummer (Long John Baldry; Jeff Beck Group), dies of liver failure at 66
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