- Apr 5 Jim Marshall, British businessman and electric guitar amplifier pioneer known as "The Father of Loud", dies at 88
- Apr 9 Dave Shriver, American rock bassist (Eddie Cochran, Trini Lopez), and music director, dies of cardiac arrest following a stroke at 76
- Apr 10 Ritchie Teeter, American drummer (The Dictators, 1976-79; Twisted Sister, 1980-81), dies of esophageal cancer at 61
- Apr 12 Andrew Love, American saxophonist (The Memphis Horns), dies of Alzheimer's disease at 70
- Apr 12 George Mesterhazy, Hungarian-American jazz pianist, and arranger, dies at 56
- Apr 17 Dimitris Mitropanos, Greek singer, dies from a heart attack at 64
- Apr 18 Robert O. Ragland, American film score composer (The Thing With Two Heads), dies at 80
- Apr 19 Greg Ham, Australian rock saxophonist and flutist (Men At Work - "Who Can It Be Now"), dies under mysterious circumstances at 58
- Apr 19 Levon Helm, American drummer and singer (The Band - "Up On Cripple Creek"; "The Weight"), and actor (Coal Miner's Daughter; The Right Stuff), dies from throat cancer at 71
- Apr 20 Bert Weedon, British jazz, pop, and blues guitar player ("Guitar Boogie Shuffle"), dies at 91
- Apr 23 Chris Ethridge, American country rock bass guitarist (International Submarine Band; The Flying Burrito Brothers), dies from pancreatic cancer at 65
- Apr 23 Tommy Marth, American rock saxophone player (the Killers, 2008-2010), dies of self-inflicted gunshot at 33
- Apr 27 Jan Bark, Swedish jazz, classical, and avant agrde trombonist and composer, dies at 78
- Apr 28 Jackie Kelso [John Joseph Kelson Jr], American jazz saxophonist & session musician, dies at 90
- Apr 29 Jim McCrary, American photographer (album covers such as Tapestry, Ticket to Ride), dies of a chronic nervous system disorder at 72
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