- Apr 3 Kishori Amonkar, Indian classical Hindustani singer, dies at 84
- Apr 5 María Luisa Ozaita, Spanish pianist, harpsichordist, musicologist, conductor, and composer (Pelleas y Melisanda), dies at 77
- Apr 9 Alan Henderson, Irish rock bassist (Them), dies at 72
- Apr 9 Bob Wootton, American country and rockabilly guitarist (Johnny Cash, 1968-97), dies of complications from dementia at 75
- Apr 10 Banner Thomas, American rock bassist (Molly Hatchet), dies of a heart attack at 63
- Apr 11 J. Geils [John Warren Geils Jr], American rock guitarist (J. Geils Band - Centerfold), dies at 71
- Apr 11 Toby Smith [Grafftey-Smith], British keyboardist and songwriter, dies of cancer at 46
- Apr 12 Barry “Frosty” Smith, American rock, country and blues touring and session drummer (Lee Michaels; Roky Erikson; Doug Sahm), dies at 71
- Apr 14 Bruce Langhorne, American session and touring folk guitarist and tambourine man, dies of kidney failure at 78
- Apr 14 Manfred Jung, German operatic tenor (Wagner's heldentenor roles), dies at 76
- Apr 15 Allan Holdsworth, British progressive rock guitarist, dies at 70
- Apr 15 Sylvia Moy, American songwriter ("My Cherie Amour"; "This Old Heart Of Mine"; "It Takes Two"), dies of pneumonia at 79
- Apr 18 Gordon Langford [Colman], British composer and arranger of brass, choral, and orchestral music (Facets of Glass; Rhapsody for Trombone), dies at 86
- Apr 20 Cuba Gooding, Sr., American pop and soul singer (The Main Ingredient - "Everybody Plays the Fool"), dies at 72
- Apr 22 Václav Kučera, Czech composer (Concierto imaginativo; Homenaje a Salvador Dalí), dies at 87
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