- Sep 2 Michel Corboz, Swiss conductor (founded L’Ensemble Vocal de Lausanne, 1961), dies at 87
- Sep 2 Mikis Theodorakis, Greek classical and film music composer (Zorba the Greek; Mauthausen Trilogy; Serpico), dies of cardiopulmonary arrest at 96
- Sep 3 Ruth Olay, American jazz and cabaret singer, dies at 97
- Sep 5 Rickie Lee Reynolds, American southern rock guitarist (Black Oak Arkansas - "Jim Dandy (To the Rescue)"), dies of COVID-19 complications, including kidney failure and heart attack at 72
- Sep 5 Sarah Harding, British pop singer (Girls Aloud - “Sound of the Underground,” “Love Machine”), dies of breast cancer at 39
- Sep 7 Phil Schaap, American Grammy Award-winning jazz historian, DJ, author and educator, dies of cancer at 70
- Sep 10 Michael Chapman, British progressive folk-rock guitarist and singer-songwriter (Looking for Eleven; Fully Qualified Survivor), dies at 80
- Sep 13 George Wein, American music promoter (Newport Jazz Festival; Newport Folk Festival; New Orleans Jazz and Heritage Festival), dies at 95
- Sep 15 Norman Bailey, British operatic bass-baritone (Flying Dutchman), dies at 88
- Sep 16 Jane Powell [Suzanne Burce], American singer and actress (Royal Wedding; Seven Brides for Seven Brothers), dies at 92
- Sep 19 Sylvano Bussotti, Italian composer, filmmaker and novelist, dies at 89
- Sep 20 Sarah Dash, American pop, R&B, and disco singer (Patti LaBelle & Bluebirds; Labelle - "Lady Marmalade"), dies at 76
Melvin Van Peebles (1932-2021)
Sep 21 American stage and screen actor, director (Sweet Sweetback's Baadasssss Song; Sophisticated Gent), composer, and novelist, dies at 89
- Sep 22 Bob Moore, American session double bassist (Patsy Cline; Elvis Presley; Roger Miller), and orchestra leader ("Mexico"), dies at 88
- Sep 23 Sue Thompson [Eva Sue McKee], American pop and country music singer ("Sad Movies (Make Me Cry")), dies at 96
- Sep 23 [Alfred] "Pee Wee" Ellis, American jazz, funk, and rock saxophonist, arranger (James Brown; Van Morrison; Maceo Parker), and songwriter ("The Chicken"; "Cold Sweat"), dies of heart failure at 80
- Sep 26 Alan Lancaster, British rock bassist (Status Quo, 1967-85 - "Pictures of Matchstick Men"), dies from multiple sclerosis complications at 72
- Sep 26 Commander Cody [George Frayne], American singer and pianist (Commander Cody & Lost Planet Airmen - "Hot Rod Lincoln"), dies of esophageal cancer at 77
- Sep 28 "Dr." Lonnie Smith, American jazz Hammond B3 organist (George Benson Quartet; Lou Donaldson), dies of pulmonary fibrosis at 79 [1]
- Sep 28 Carlisle Floyd, American opera composer (Susanna; Prince of Players), dies at 95
- Sep 29 Bronius Kutavičius, Lithuanian composer (The Gates of Jerusalem; Lokys) and teacher (Čiurlionis School of Art, 1975-2000), dies at 89
- Sep 30 Koichi Sugiyama, Japanese television and video game composer (Dragon Quest), and Nanjing Massacre denialist, dies at 90
Country Singers
Jazz Singers
Opera Singers
Pop Singers
Rappers
Rock Singers