Born in 1380
- Feb 11 Poggio Bracciolini, Italian humanist who rediscovered lost classical texts, born in Terranuova, Republic of Florence (d. 1459)
- Mar 18 Lidwina, Dutch mystic (Christ's Bride) and saint, born in Schiedam, Netherlands (d. 1433)
- Sep 8 Bernardino of Siena, Italian priest and Franciscan missionary, born in Massa Marittima, Italy (d. 1444)
Who Died in 1380
- Apr 29 Catherine of Siena, Italian Dominican saint and Doctor of the Church (The Dialogue of Divine Providence), dies at 33
- Jul 13 Bertrand du Guesclin, French King of Granada, dies at about 60
- Jul 26 Emperor Kōmyō of Japan, 2nd Northern Emperor (1336-48), dies at 58
- Sep 16 Charles V, the Wise, King of France during Hundred Years' (1364-80), dies at 42
- Dec 24 John von Neumarkt, German bishop/Chancellor Karel IV, dies
Gregory I
Gregory XIII
Julius II
Julius III
Leo X
Pius V