Historical Events Jun 13 England signs Treaty of Madrid Jun 26 Dr Zabdiel Boylston gives 1st smallpox inoculations in America Events in 1721 May 1721 History by Year Jul 1721 Famous People by Star Sign ♈︎ Aries ♉︎ Taurus ♊︎ Gemini ♋︎ Cancer ♌︎ Leo ♍︎ Virgo ♎︎ Libra ♏︎ Scorpio ♐︎ Sagittarius ♑︎ Capricorn ♒︎ Aquarius ♓︎ Pisces