Major Events Battle of the Granicus May 22 The Macedonian army of Alexander the Great defeats Darius III of Persia in the Battle of the Granicus Articles About 334 Battle of the Granicus The Greeks crossed the Granique, which closed the entrance to Asia, despite the trunks of trees gathered on the banks of the riverMay 22 338 BC History by Year 331 BC Famous Romans Augustus Caesar Caligula Constantine the Great Julius Caesar Mark Antony Nero