- Jan 3 Friedrich Witt, German cellist and composer (Jena Symphony; The Suffering Saviour), dies at 65
- Feb 22 John Clarke-Whitfeld, English organist and composer, dies at 65
- May 6 Christian Ignatius Latrobe, English clergyman and composer (Selection of Sacred Music), dies at 78
- May 7 Norbert Burgmuller, German composer, drowns during an epileptic seizure at 26
- May 28 Anton Reicha, Czech-French composer, and pedagogue, dies at 66
- Jun 9 Supply Belcher, American composer and singer (The Harmony of Maine), dies at 85
- Jun 26 Claude-Joseph Rouget de Lisle, French author and composer (Marseillaise), dies at 76
- Jul 26 José Melchor Gomis, Spanish Romantic composer, dies of tuberculosis at 45 [some source date death as 4 August]
- Sep 14 Vincenzo Lavigna, Italian composer, dies at 60
- Sep 19 Carl Friedrich Ebers, German composer and conductor, dies at 66
- Sep 21 John Stafford Smith, British organist, and composer ("The Anacreontic Song", later used for the American national anthem "The Star-Spangled Banner"), dies at 86
- Sep 23 María Malibran (née García) Spanish operatic contralto and soprano, dies from head injuries several months after falling from a horse at 28
- Oct 10 Jacob-Joseph-Balthasar Martinn, Flemish composer, dies at 61
- Oct 16 Friedrich Theodor Frohlich, composer, dies at 33
- Dec 4 Daniel Read, American composer, dies at 79
- Dec 12 Giuseppe Farinelli, Italian composer, dies at 67
- Dec 26 Hans Georg Nägeli, Swiss composer, dies at 63
- Dec 29 Johann Baptist Schenk, Austrian composer, dies at 83
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