- Oct 1 Beverly "Guitar" Watkins, American blues guitarist, and singer, dies of a heart attack at 80
- Oct 1 Karel Gott, Czech singer 'Sinatra of the East', dies at 80
- Oct 2 Barrie Masters, British pub-rock singer (Eddie & the Hot Rods - "Teenage Depression"), dies of drug intoxication at 63
- Oct 2 Giya Kancheli, Georgian composer (NightPrayers; Exil), dies at 84
- Oct 3 Vinnie Bell [Gambella], American session guitarist, electric sitar player, and pioneer of electronic effects in pop music, dies at 87
- Oct 5 Larry Junstrom, American rock bassist (.38 Special), dies at 70
- Oct 5 Marcello Giordani, Italian tenor (Metropolitan Opera, 1993-2008), dies of a heart attack at 56
- Oct 6 [Peter] "Ginger" Baker, English drummer (Cream), dies at 80
- Oct 8 (Malcolm) "Molly" Duncan, Scottish saxophonist (Average White Band, 1972-83 - "Pick Up the Pieces"), dies of cancer at 74
- Oct 12 George Chambers, American rock bassist and vocalist (Chambers Brothers - "Time Has Come Today"), dies at 88
- Oct 13 Steve Cash, American country-rock vocalist, songwriter, and harmonica player (Ozark Mountain Daredevils - "Jackie Blue", "If You Wanna Get To Heaven"), and author (Meq trilogy), dies at 73
- Oct 14 Sulli [Choi Jin-ri], South Korean K-pop singer (f(x)) and actress (Fashion King), takes her own life at 25
- Oct 15 Hossein Dehlavi, Persian composer, conductor and teacher (Sarbaz; Plectrum Orchestra), dies of Alzheimer complications at 92
- Oct 17 Alicia Alonso, Cuban ballerina and founder of the National Ballet of Cuba, dies at 98
- Oct 17 Márta Kurtág [née Kinsker], Hungarian classical pianist, dies at 92
- Oct 22 Hans Zender, German composer and conductor (Stephen Climax; Chief Joseph), dies at 82
- Oct 22 Ramon Zupko, American classical and electro-acoustic composer (Fluxus), and educator (Western Michigan University, 1971-96), dies at 86
- Oct 22 Raymond Leppard, British-American harpsichordist, conductor (Indianapolis Symphony, 1987-2001; BBC Northern Symphony, 1973-80), and composer (Lord Of The Flies), dies at 93
- Oct 23 Hansheinz Schneeberger, Swiss violinist (Duo Paganini), dies at 93
- Oct 25 Chou Wen-chung, Chinese-American composer (Mode of Shang), dies at 96
- Oct 26 Paul Barrere, American rock guitarist (Little Feat - "Time Loves a Hero"), dies of liver cancer at 71
- Oct 28 Zoltán Jeney, Hungarian composer and educator (Franz Liszt Academy, 1995-2019), dies at 76
- Oct 31 (Elizabeth) Ann Crumb, American stage and screen actress and singer, dies of ovarian cancer at 69