- Sep 5 Jimmy Johnson, American session guitarist and co-founder of the Muscle Shoals Sound Studio, dies at 76
- Sep 8 Camilo Sesto, Spanish singer (Perdóname, El Amor De Mi Vida), dies of kidney failure at 72
- Sep 11 Daniel Johnston, American musician and visual artist ("Hi, How Are You"), dies of a suspected heart attack at 58
- Sep 13 Eddie Money [Mahoney], American rock singer-songwriter ("Two Tickets To Paradise"; 'Take Me Home Tonight"), dies of esophageal cancer at 70
- Sep 15 Phyllis Newman, American Tony Award-winning actress (Subways Are for Sleeping: Coming of Age), and singer, dies of lung disease at 86
- Sep 15 Ric Ocasek [Otcasek], American rock singer-songwriter (The Cars - "Best Friend's Girl"; "Shake It Up"; "You Are The Girl"), found dead at 75
- Sep 16 Vic Vogel, Hungarian-Canadian pianist, composer and bandleader, dies at 84
- Sep 17 Harold Mabern Jr., American post-bop jazz pianist and composer, dies at 83
- Sep 21 Christopher Rouse, American Grammy Award-winning composer (Trombone Concerto - Pulitzer Prize for Music, 1993), and educator (Eastman School, 1981-2002; Juilliard, 1997-2017), dies of renal cancer at 70
- Sep 23 Robert Hunter, American lyricist and singer-songwriter (Grateful Dead), dies at 78
- Sep 25 Paul Badura-Skoda, Austrian pianist (Mozart interpretation), dies at 91
- Sep 26 Martin Wesley-Smith, Australian composer, dies at 74
- Sep 27 Bob Etsy, American songwriter, producer, and arranger, dies of metastatic cancer at 72
- Sep 28 José José 'The Prince of Song' [José Rómulo Sosa Ortiz], Mexican singer and actor, dies at 71
- Sep 29 Larry Willis, American jazz pianist and composer, dies of an aneurysm at 76
Jessye Norman (1945-2019)
Sep 30 American opera singer (sang at two presidential inaugurations), dies at 74
Country Singers
Jazz Singers
Opera Singers
Pop Singers
Rappers
Rock Singers