Historical Events Treaty of Madrid Jan 14 Charles V and Francis I sign the Treaty of Madrid, forcing Francis to give up claims to Burgundy, Italy and Flanders Holy Roman Emperor Charles V King Francis I of France Famous Deaths Jan 19 Isabella of Burgundy, wife of Christian II of Denmark, dies at 24 Dec 1525 History by Year Feb 1526 What Happened in 1526 First Battle of PanipatApril 21, 1526